HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → N-Cyclopropyl-3-fluoro-4-oxazol-5-yl-N-piperidin-4-yl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl 4-(cyclopropylamino)piperidine-1-carboxylate | HCID 2769591 | — |
| Reactant | 3-Fluoro-4-oxazol-5-yl-benzoic acid | HCID 68290144 | — |
| Reactant | 1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonitrile | HCID 86678210 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-Cyclopropyl-3-fluoro-4-oxazol-5-yl-N-piperidin-4-yl-benzamide | HCID 68290215 | — |
Reaction Steps
The title compound is prepared from 4-cyclopropylamino-piperidine-1-carboxylic acid tert-butyl ester and 3-fluoro-4-oxazol-5-yl-benzoic acid following a procedure analogous to that described in Intermediate 1. The cleavage of the BOC group is accomplished by using trifluoroacetic acid in dichloromethane. LC (method 14): tR=0.98 min; Mass spectrum (ESI+): m/z=330 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822471B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-f1e437eebe564c5b95d16d602c980288 |
| Source note | uspto-grants-2014_09 |