Cyclopropylamine → Cyclopropyl-(3'-fluoro-5'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-amine

Reaction equation

[F:1][C:2]1[C:3]([N:12]2[CH2:17][CH2:16][C:15](=O)[CH2:14][CH2:13]2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[CH:19]1([NH2:22])[CH2:21][CH2:20]1>>[CH:19]1([NH:22][CH:15]2[CH2:16][CH2:17][N:12]([C:3]3[C:2]([F:1])=[CH:7][C:6]([C:8]([F:11])([F:10])[F:9])=[CH:5][N:4]=3)[CH2:13][CH2:14]2)[CH2:21][CH2:20]1

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 682895791-(3-Fluoro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-one

Product 1

HCID 68289864Cyclopropyl-(3'-fluoro-5'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-amine

Procedure

The title compound is prepared from 1-(3-fluoro-5-trifluoromethyl-pyridin-2-yl)-piperidin-4-one and cyclopropylamine following a procedure analogous to that described for Intermediate 66.

Sources & evidence

ORD record: ord-bbd096257b6547ab813b2468da0de363
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08822471B2

Reaction notes

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