2-Chloro-5-ethylpyrimidine → (3R,4S)-Cyclopropyl-[1-(5-ethyl-pyrimidin-2-yl)-3-fluoro-piperidin-4-yl]-amine

HRID 68800

Reaction equation

HRID 68800 reaction equation
C(OC(=O)[N:7]([CH:15]1[CH2:17][CH2:16]1)[C@H:8]1[CH2:13][CH2:12][NH:11][CH2:10][C@H:9]1[F:14])(C)(C)C.Cl[C:20]1[N:25]=[CH:24][C:23]([CH2:26][CH3:27])=[CH:22][N:21]=1>>[CH:15]1([NH:7][C@H:8]2[CH2:13][CH2:12][N:11]([C:20]3[N:25]=[CH:24][C:23]([CH2:26][CH3:27])=[CH:22][N:21]=3)[CH2:10][C@H:9]2[F:14])[CH2:16][CH2:17]1

Participants

3

Reactant 2

HCID 35727632-Chloro-5-ethylpyrimidineHCID 68289942HCID 68289942, compound

Product 1

HCID 68290756(3R,4S)-Cyclopropyl-[1-(5-ethyl-pyrimidin-2-yl)-3-fluoro-piperidin-4-yl]-amine

Procedure

The title compound is prepared from cyclopropyl-[(3R,4S)-3-fluoro-piperidin-4-yl]-carbamic acid tert-butyl ester and 2-chloro-5-ethyl-pyrimidine following a procedure analogous to that described for Intermediate 73.

Sources & evidence

ORD record
ord-4f4240851600414389af3338dc926741
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Linked notes

Loading…