Propionyl chloride → N-Cyclopropyl-N-[1-(5-ethyl-[1,2,4]oxadiazol-3-yl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide
Reaction equation
[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][N:21]([C:24](=[NH:27])[NH:25][OH:26])[CH2:20][CH2:19]2)[C:5](=[O:17])[C:6]2[CH:11]=[CH:10][C:9]([C:12]3[O:16][CH:15]=[N:14][CH:13]=3)=[CH:8][CH:7]=2)[CH2:3][CH2:2]1.[C:28](Cl)(=O)[CH2:29][CH3:30]>>[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][N:21]([C:24]3[N:27]=[C:28]([CH2:29][CH3:30])[O:26][N:25]=3)[CH2:20][CH2:19]2)[C:5](=[O:17])[C:6]2[CH:11]=[CH:10][C:9]([C:12]3[O:16][CH:15]=[N:14][CH:13]=3)=[CH:8][CH:7]=2)[CH2:3][CH2:2]1Participants
3
Procedure
The title compound is prepared from N-cyclopropyl-N-[1-(N-hydroxycarbamimidoyl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide and propionyl chloride following a procedure analogous to that described in Example 47. LC (method 3): tR=1.83 min; Mass spectrum (ESI+): m/z=408 [M+H]+.
Sources & evidence
- ORD record
- ord-5a2bb96b396c41388b85bea81232f762
- Source dataset
- uspto-grants-2014_09