HCID 68289598, compound → N-Cyclopropyl-3-fluoro-4-oxazol-5-yl-N-[1-(3-propyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-benzamide

HRID 68860

Reaction equation

HRID 68860 reaction equation
Cl.[CH:2]1([NH:5][CH:6]2[CH2:11][CH2:10][N:9]([C:12]3[O:16][N:15]=[C:14]([CH2:17][CH2:18][CH3:19])[N:13]=3)[CH2:8][CH2:7]2)[CH2:4][CH2:3]1.[F:20][C:21]1[CH:22]=[C:23]([CH:27]=[CH:28][C:29]=1[C:30]1[O:34][CH:33]=[N:32][CH:31]=1)[C:24](O)=[O:25]>>[CH:2]1([N:5]([CH:6]2[CH2:11][CH2:10][N:9]([C:12]3[O:16][N:15]=[C:14]([CH2:17][CH2:18][CH3:19])[N:13]=3)[CH2:8][CH2:7]2)[C:24](=[O:25])[C:23]2[CH:27]=[CH:28][C:29]([C:30]3[O:34][CH:33]=[N:32][CH:31]=3)=[C:21]([F:20])[CH:22]=2)[CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 68289598HCID 68289598, compoundHCID 682901443-Fluoro-4-oxazol-5-yl-benzoic acid

Product 1

HCID 68351905N-Cyclopropyl-3-fluoro-4-oxazol-5-yl-N-[1-(3-propyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-benzamide

Procedure

The title compound is prepared from cyclopropyl-[1-(3-propyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amine hydrochloride and 3-fluoro-4-oxazol-5-yl-benzoic acid following a procedure analogous to that described in Example 17. LC (method 1): tR=1.20 min; Mass spectrum (ESI+): m/z=440 [M+H]+.

Sources & evidence

ORD record
ord-ea9c19d85fb94ca18791beac735d358f
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Linked notes

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