Dichloromethane → 5-Chloromethyl-4-(2-methoxy-ethyl)-6-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidine

Reaction equation

[CH3:1][O:2][CH2:3][CH2:4][c:5]1[n:6][c:7](-[c:14]2[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]2)[n:8][c:9]([CH3:13])[c:10]1[CH2:11][OH:12].[Cl:28][CH2:29][Cl:30].[S:24]([Cl:25])([Cl:26])=[O:27]>>[CH3:1][O:2][CH2:3][CH2:4][c:5]1[n:6][c:7](-[c:14]2[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]2)[n:8][c:9]([CH3:13])[c:10]1[CH2:11][Cl:26]

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 24386Thionyl Chloride

HCID 21935907[4-(2-Methoxy-ethyl)-6-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-methanol

Product 1

HCID 219357495-Chloromethyl-4-(2-methoxy-ethyl)-6-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidine

Sources & evidence

ORD record: ord-0576d695817a44d49703d11378ee0815
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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