HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazo[1,2-a]pyridine-6-carbaldehyde → 5-Fluoro-6-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazo[1,2-a]pyridine-6-carbaldehyde | HCID 7164582 | — |
| Reactant | 5-Fluoroquinoline-6-carbaldehyde | HCID 57917315 | — |
| Reactant | 3-Bromo-6-(1-methyl-1h-pyrazol-4-yl)-imidazo[1,2-b]pyridazine | HCID 68632486 | — |
| Product | 5-Fluoro-6-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline | HCID 57917488 | — |
Reaction Steps
(rac)-(5-Fluoro-quinolin-6-yl)-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-methanol was obtained analogously to Stage 9.1 by replacing 3-bromo-6-chloro-imidazo[1,2-b]pyridazine with 3-bromo-6-(1-methyl-1h-pyrazol-4-yl)-imidazo[1,2-b]pyridazine (Stage 8.1) and imidazo[1,2-a]pyridine-6-carbaldehyde with 5-fluoro-quinoline-6-carbaldehyde (Intermediate A) (tR 0.90 min (conditions 1), (MH+=375).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822468B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-439889cdcf884be28c6710a5346c474e |
| Source note | uspto-grants-2014_09 |