Hydrogen chloride-ethyl acetate → 4-Methoxybutyric acid hydrazide hydrochloride salt

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Reaction Steps

N′-(4-Methoxybutyryl)hydrazine carboxylic acd tert-butyl ester (9.30 g) was dissolved in ethyl acetate (50 ml), followed by addition of 4 mol/liter hydrochloric acid/ethyl acetate solution (150 ml), and stirred at ambient temperature for 2 hours. After the reaction solution was concentrated under reduced pressure, the resulting residue was washed with n-hexane, to afford 4-methoxybutyric acid hydrazide hydrochloride salt as pale yellow solid (5.99 g, 89%). The physico-chemical values are as follows.

Provenance & Evidence