Acetone → 6-Butoxy-2-{3-fluoro-4-[(R)-3-(isopropylmethylamino)pyrrolidin-1-yl]phenyl}-3,4-dihydro-2H-isoquinolin-1-one

HRID 69411

Reaction equation

HRID 69411 reaction equation
[CH2:1]([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[C:12](=[O:16])[N:11]([C:17]1[CH:22]=[CH:21][C:20]([N:23]3[CH2:27][CH2:26][C@@H:25]([NH:28][CH3:29])[CH2:24]3)=[C:19]([F:30])[CH:18]=1)[CH2:10][CH2:9]2)[CH2:2][CH2:3][CH3:4].[CH3:31][C:32]([CH3:34])=O>>[CH2:1]([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[C:12](=[O:16])[N:11]([C:17]1[CH:22]=[CH:21][C:20]([N:23]3[CH2:27][CH2:26][C@@H:25]([N:28]([CH:32]([CH3:34])[CH3:31])[CH3:29])[CH2:24]3)=[C:19]([F:30])[CH:18]=1)[CH2:10][CH2:9]2)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 180AcetoneHCID 248595776-Butoxy-2-[3-fluoro-4-((R)-3-methylaminopyrrolidin-1-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one

Product 1

HCID 248597116-Butoxy-2-{3-fluoro-4-[(R)-3-(isopropylmethylamino)pyrrolidin-1-yl]phenyl}-3,4-dihydro-2H-isoquinolin-1-one

Procedure

6-Butoxy-2-[3-fluoro-4-((R)-3-methylaminopyrrolidin-1-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one (hydrochloride) was reductively alkylated with acetone by method J. The product with the molecular weight of 453.61 (C27H36FN3O2) was obtained in this way; MS (ESI): 454 (M+H+).

Workup

  1. customThe product with the molecular weight of 453.61 (C27H36FN3O2) was obtained in this way

Sources & evidence

ORD record
ord-575e3cc6f39447a2bf39d20582648f94
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Linked notes

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