HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 2-[4-((R)-3-Dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-6-piperidin-1-yl-3,4-dihydro-2H-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Trifluoromethanesulfonic acid 2-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl ester | HCID 86635103 | — |
| Product | 2-[4-((R)-3-Dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-6-piperidin-1-yl-3,4-dihydro-2H-isoquinolin-1-one | HCID 57916720 | — |
Reaction Steps
Trifluoromethanesulfonic acid 2-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl ester was reacted with piperidine by method N. The product with the molecular weight of 436.58 (C26H33FN40) was obtained in this way; MS (ESI): 437 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822495B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-b5d62fd80fe848b1ba2addd59d948f38 |
| Source note | uspto-grants-2014_09 |