Butanal → 1,1-Di-(7-azaindol-3-yl)-butane

HRID 6943

Reaction equation

HRID 6943 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[CH:3]=[CH:2]1.[CH:10](=O)[CH2:11][CH2:12][CH3:13]>>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[C:3]([CH:10]([C:3]2[C:4]3[C:9](=[N:8][CH:7]=[CH:6][CH:5]=3)[NH:1][CH:2]=2)[CH2:11][CH2:12][CH3:13])=[CH:2]1

Participants

3

Reactant 2

HCID 261ButanalHCID 92221H-Pyrrolo(2,3-b)pyridine

Product 1

HCID 220192831,1-Di-(7-azaindol-3-yl)-butaneYield 15%

Procedure

ST 1436 was prepared as described in example 2/2 from 7-azaindole and butyraldehyde. The reaction, however, was heated under reflux for 48 hours. The end product was isolated and purified chromatographically on a silica column eluting with a CH2Cl2:CH3COCH3 gradient ranging from 9:1 to 4:6. Yield 15%.

Workup

  1. customST 1436 was prepared
  2. customThe reaction
  3. temperaturehowever, was heated
  4. temperatureunder reflux for 48 hours
  5. customThe end product was isolated
  6. custompurified chromatographically on a silica column
  7. washeluting with a CH2Cl2

Sources & evidence

ORD record
ord-7e699b14c36a4cb1ab9bfad78d80f704
Source dataset
uspto-grants-2006_08
Patent number
US07084166B2

Linked notes

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