HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-Chloroethyl)-4-methoxybenzoyl chloride → (S)-7-[4-(6-methoxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-phenyl]-2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-Chloroethyl)-4-methoxybenzoyl chloride | HCID 12401186 | — |
| Reactant | (S)-7-(4-amino-phenyl)-2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester | HCID 68994472 | — |
| Product | (S)-7-[4-(6-methoxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-phenyl]-2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester | HCID 68990290 | — |
Reaction Steps
According to Method A, 2-(2-chloroethyl)-4-methoxy-benzoyl chloride was reacted with (S)-7-(4-amino-phenyl)-2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester. In this way the product was obtained with molecular weight 477.61 (C28H35N3O4); MS (ESI): 478 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822495B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-bdcf3269df004ea8a7f86e53f38608ea |
| Source note | uspto-grants-2014_09 |