HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Formylmorpholine → (S)-7-[4-(6-methoxy-1-oxo-1H-isoquinolin-2-yl)-phenyl]-2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Formylmorpholine | HCID 20417 | — |
| Reactant | (S)-7-[4-(4-methoxy-2-methyl-benzoylamino)-phenyl]-2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester | HCID 68990294 | — |
| Product | (S)-7-[4-(6-methoxy-1-oxo-1H-isoquinolin-2-yl)-phenyl]-2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester | HCID 68991895 | — |
Reaction Steps
According to Method Q, (S)-7-[4-(4-methoxy-2-methyl-benzoylamino)-phenyl]-2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester was reacted with N-formylmorpholine. In this way the product was obtained with molecular weight 475.59 (C28H33N3O4); MS (ESI): 476 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822495B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-25f4184ad4484b859f623f7b0c021127 |
| Source note | uspto-grants-2014_09 |