Tert-butyl 1,4-diazepane-1-carboxylate → 4-(4-Amino-2-methoxyphenyl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester

HRID 69472

Reaction equation

HRID 69472 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[O:11][CH3:12].[C:13]([O:17][C:18]([N:20]1[CH2:26][CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)=[O:19])([CH3:16])([CH3:15])[CH3:14]>>[C:13]([O:17][C:18]([N:20]1[CH2:26][CH2:25][CH2:24][N:23]([C:2]2[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=2[O:11][CH3:12])[CH2:22][CH2:21]1)=[O:19])([CH3:16])([CH3:14])[CH3:15]

Participants

3

Reactant 2

HCID 2756058Tert-butyl 1,4-diazepane-1-carboxylateHCID 144519681-Fluoro-2-methoxy-4-nitrobenzene

Product 1

HCID 689879374-(4-Amino-2-methoxyphenyl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester

Procedure

According to methods E and F 1-Fluoro-2-methoxy-4-nitro-benzene was reacted with [1,4]Diazepane-1-carboxylic acid tert-butyl ester and then the obtained nitro compound was hydrogenated. In this way the product was obtained with molecular weight 321.42 (C17H27N3O3); MS (ESI): 322 (M+H+).

Workup

  1. customIn this way the product was obtained with molecular weight 321.42 (C17H27N3O3)

Sources & evidence

ORD record
ord-46ebcc912ded4a09b955b2dfa48c94fb
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Linked notes

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