4-Bromo-3-fluoroaniline → 2-(4-Bromo-3-fluorophenyl)-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-2H-isoquinolin-1-one

HRID 69494

Reaction equation

HRID 69494 reaction equation
[O:1]1[CH2:5][CH2:4][CH2:3][C@@H:2]1[CH2:6][O:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[C:14](=[O:18])O[CH:12]=[CH:11]2.[Br:19][C:20]1[CH:25]=[CH:24][C:23]([NH2:26])=[CH:22][C:21]=1[F:27]>>[Br:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]2[CH:12]=[CH:11][C:10]3[C:15](=[CH:16][CH:17]=[C:8]([O:7][CH2:6][C@H:2]4[CH2:3][CH2:4][CH2:5][O:1]4)[CH:9]=3)[C:14]2=[O:18])=[CH:22][C:21]=1[F:27]

Participants

3

Reactant 2

HCID 8218484-Bromo-3-fluoroanilineHCID 668789366-[(R)-1-(Tetrahydrofuran-2-yl)methoxy]isochromen-1-one

Product 1

HCID 689912162-(4-Bromo-3-fluorophenyl)-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-2H-isoquinolin-1-one

Procedure

6-[(R)-1-(Tetrahydrofuran-2-yl)methoxy]-isochromen-1-one and 4-bromo-3-fluorophenylamine were reacted according to Method AJ. In this way the product was obtained with molecular weight 418.27 (C20H17BrFNO3); MS (ESI): 418 and 420 (M+H+).

Workup

  1. customIn this way the product was obtained with molecular weight 418.27 (C20H17BrFNO3)

Sources & evidence

ORD record
ord-3e2231314d8945f984affa0192254ed6
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Linked notes

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