1,4'-Bipiperidine → [2-(4-Tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydroimidazol-1-yl]-(4-piperidin-1-ylpiperidin-1-yl)methanone

Reaction equation

[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([O:33][CH2:34][CH3:35])[c:8]([C:11]2=[N:15][CH:14]([c:16]3[cH:17][cH:18][c:19]([Cl:22])[cH:20][cH:21]3)[CH:13]([c:23]3[cH:24][cH:25][c:26]([Cl:29])[cH:27][cH:28]3)[N:12]2[C:30](=[O:31])[Cl:32])[cH:9][cH:10]1.[N:36]1([CH:42]2[CH2:43][CH2:44][NH:45][CH2:46][CH2:47]2)[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([O:33][CH2:34][CH3:35])[c:8]([C:11]2=[N:15][CH:14]([c:16]3[cH:17][cH:18][c:19]([Cl:22])[cH:20][cH:21]3)[CH:13]([c:23]3[cH:24][cH:25][c:26]([Cl:29])[cH:27][cH:28]3)[N:12]2[C:30](=[O:31])[N:45]2[CH2:44][CH2:43][CH:42]([N:36]3[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41]3)[CH2:47][CH2:46]2)[cH:9][cH:10]1

Participants

Reactant 2

HCID 786071,4'-Bipiperidine

HCID 87323557Racemic-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride

Product 1

HCID 73037272[2-(4-Tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydroimidazol-1-yl]-(4-piperidin-1-ylpiperidin-1-yl)methanone

Sources & evidence

ORD record: ord-3597ac1b648b424b89f04d4c1bd79c07
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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