HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Fluoro-2-nitrobenzene → Tert-butyl 1-(2-nitrophenyl)piperidin-3-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-(Boc-amino)piperidine | HCID 4233041 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Tert-butyl 1-(2-nitrophenyl)piperidin-3-ylcarbamate | HCID 68162429 | 85% |
Reaction Steps
The method of Example 1 was followed using 1-fluoro-2-nitrobenzene (1.0 eq), 3-N-Boc-aminopiperidine (1.0 eq), and DIEA (2.0 eq) in EtOH at 50° C. for 48 hours yielding tert-butyl 1-(2-nitrophenyl)piperidin-3-ylcarbamate (85%). LCMS (m/z): 322.2 (MH+); LC Rt=3.23 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-d70960dc09ae40e8bb85428a1a0e5f1b |
| Source note | uspto-grants-2014_09 |