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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 69839Generated: October 23, 2026

2,4-Difluoronitrobenzene → Tert-butyl 1-(5-fluoro-2-nitrophenyl)-piperidin-4-ylcarbamate

https://huagongshe.com/en/reaction/69839

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,4-DifluoronitrobenzeneHCID 67967—
Reactant4-(N-Boc-amino)piperidineHCID 723833—
ProductTert-butyl 1-(5-fluoro-2-nitrophenyl)-piperidin-4-ylcarbamateHCID 6904486893%

Reaction Steps

Method 1 was followed using 1 eq each of 1,3-difluoro-4-nitrobenzene, 4-(N-Boc-amino) piperidine, and TEA yielding tert-butyl 1-(5-fluoro-2-nitrophenyl)-piperidin-4-ylcarbamate (93%). LCMS (m/z): 340.1 (MH+); LC Rt=3.24 min.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08822497B2
Source datasetuspto-grants-2014_09
ORD IDord-b0546e3539b24065b65fdd9cab43f212
Source noteuspto-grants-2014_09