HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Difluoronitrobenzene → tert-Butyl 1-(4-fluoro-2-nitrophenyl)piperidine-4-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Difluoronitrobenzene | HCID 67767 | — |
| Reactant | 4-(N-Boc-amino)piperidine | HCID 723833 | — |
| Product | tert-Butyl 1-(4-fluoro-2-nitrophenyl)piperidine-4-ylcarbamate | HCID 53255560 | 97% |
Reaction Steps
Method 1 was followed using 2,5-difluoronitrobenzene (1.0 eq), 4-(N-Boc-amino) piperidine (1.4 eq), and TEA (2.0 eq) at 55° C. overnight yielding tert-butyl 1-(4-fluoro-2-nitrophenyl)piperidin-4-ylcarbamate (97%). LCMS (m/z): 340.1 (MH+); LC Rt=3.28 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-87bc047f054448d0b22fed296455b5f1 |
| Source note | uspto-grants-2014_09 |