HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-3-nitrobenzophenone → Tert-butyl 4-(4-benzoyl-2-nitrophenyl)piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-3-nitrobenzophenone | HCID 41743 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | Tert-butyl 4-(4-benzoyl-2-nitrophenyl)piperazine-1-carboxylate | HCID 69045013 | 93% |
Reaction Steps
Method 1 was followed using 4-chloro-3-nitrobenzophenone (1.0 eq), 1-Boc-piperazine (1.1 eq), and TEA (2.0 eq) in NMP yielding tert-butyl 4-(4-benzoyl-2-nitrophenyl)piperazine-1-carboxylate (93%). LCMS (m/z): 412.2 (MH+); LC Rt=3.59 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-6248ee4f40be43a3b83ec9a4dcedc2ad |
| Source note | uspto-grants-2014_09 |