HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-3-nitroanisole → Tert-butyl 1-(4-methoxy-2-nitrophenyl)piperidin-4-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-3-nitroanisole | HCID 25140 | — |
| Reactant | 4-(N-Boc-amino)piperidine | HCID 723833 | — |
| Product | Tert-butyl 1-(4-methoxy-2-nitrophenyl)piperidin-4-ylcarbamate | HCID 69044880 | 75% |
Reaction Steps
Method 1 was followed using 4-chloro-3-nitroanisole (1.0 eq), 4-(N-Boc-amino) piperidine (1.2 eq), and TEA (2.0 eq) at 60° C. for 72 hours yielding tert-butyl 1-(4-methoxy-2-nitrophenyl)piperidin-4-ylcarbamate (75%). LCMS (m/z): 352.1 (MH+); LC Rt=3.22 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-8491026ea44046b583af8cd9bc37cb9c |
| Source note | uspto-grants-2014_09 |