HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-1-fluoro-2-nitrobenzene → Tert-butyl 4-(4-chloro-2-nitrophenyl)piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-1-fluoro-2-nitrobenzene | HCID 67660 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Product | Tert-butyl 4-(4-chloro-2-nitrophenyl)piperazine-1-carboxylate | HCID 69042278 | 95% |
Reaction Steps
Method 1 was followed using 1 eq each of 4-chloro-1-fluoro-2-nitrobenzene, 1-Boc-piperazine, and TEA yielding tert-butyl 4-(4-chloro-2-nitrophenyl)piperazine-1-carboxylate (95%). LCMS (m/z): 342.0 (MH+); LC Rt=3.50 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-493f2fb4bdf94f1195a23c1bda9ad657 |
| Source note | uspto-grants-2014_09 |