HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-1-fluoro-2-nitrobenzene → Tert-butyl 1-(4-chloro-2-nitrophenyl)piperidin-4-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-1-fluoro-2-nitrobenzene | HCID 67660 | — |
| Reactant | 4-(N-Boc-amino)piperidine | HCID 723833 | — |
| Product | Tert-butyl 1-(4-chloro-2-nitrophenyl)piperidin-4-ylcarbamate | HCID 60507369 | 95% |
Reaction Steps
Method 1 was followed using 1 eq each of 4-chloro-1-fluoro-2-nitrobenzene, 4-N-Boc-aminopiperidine, and TEA yielding tert-butyl 1-(4-chloro-2-nitrophenyl)piperidin-4-ylcarbamate (95%). LCMS (m/z): 356.1 (MH+); LC Rt=3.43 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-1b4d6d66c9664121b987a3580cc061ac |
| Source note | uspto-grants-2014_09 |