HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-3-nitrobenzotrifluoride → Tert-butyl 4-(2-nitro-4-(trifluoromethyl)phenyl)piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-3-nitrobenzotrifluoride | HCID 67778 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Product | Tert-butyl 4-(2-nitro-4-(trifluoromethyl)phenyl)piperazine-1-carboxylate | HCID 53426214 | 99% |
Reaction Steps
Method 1 was followed using 1-fluoro-2-nitro-4-(trifluoromethyl)benzene (1.0 eq), 1-Boc-piperazine (1.2 eq), and TEA (2.0 eq) at 55° C. for 1 hour yielding tert-butyl 4-(2-nitro-4-(trifluoro-methyl)phenyl)piperazine-1-carboxylate (99%). LCMS (m/z): 376.1 (MH+); LC Rt=3.58 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-dc7f86ab6e084595af607ed7b124cc89 |
| Source note | uspto-grants-2014_09 |