HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 4-(2-nitro-4-(trifluoromethyl)phenyl)piperazine-1-carboxylate → tert-Butyl 4-[2-amino-4-(trifluoromethyl)phenyl]piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 4-(2-nitro-4-(trifluoromethyl)phenyl)piperazine-1-carboxylate | HCID 53426214 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | tert-Butyl 4-[2-amino-4-(trifluoromethyl)phenyl]piperazine-1-carboxylate | HCID 53426177 | 99% |
Reaction Steps
Following the method of Example 49 (Method 2), tert-butyl 4-(2-nitro-4-(trifluoro-methyl)phenyl)piperazine-1-carboxylate in MeOH was reduced yielding tert-butyl 4-(2-amino-4-(trifluoromethyl)phenyl)piperazine-1-carboxylate (99%). LCMS (m/z): 346.1 (MH+); LC Rt=3.38 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-05943aaf658c44c99e7446df3ab7a65b |
| Source note | uspto-grants-2014_09 |