Methyl DL-leucinate hydrochloride → Methyl 4-methyl-2-[[5-morpholin-4-yl-6-(2,2,2-trifluoroethoxy)pyrazine-2-carbonyl]amino]pentanoate

Reaction equation

[CH3:47][O:48][C:49]([CH:50]([NH2:51])[CH2:52][CH:53]([CH3:54])[CH3:55])=[O:56].[O:26]1[CH2:27][CH2:28][N:29]([c:32]2[n:33][cH:34][c:35]([C:44](=[O:45])[OH:46])[n:36][c:37]2[O:38][CH2:39][C:40]([F:41])([F:42])[F:43])[CH2:30][CH2:31]1.[OH:1][CH2:2][CH:3]([NH:4][C:5]([c:6]1[cH:7][n:8][c:9]([N:10]2[CH2:11][CH2:12][CH2:13][CH2:14]2)[c:15]([O:16][CH2:17][CH2:18][CH3:19])[n:20]1)=[O:21])[CH2:22][CH:23]([CH3:24])[CH3:25]>>[O:26]1[CH2:27][CH2:28][N:29]([c:32]2[n:33][cH:34][c:35]([C:44](=[O:46])[NH:51][CH:50]([C:49]([O:48][CH3:47])=[O:56])[CH2:52][CH:53]([CH3:54])[CH3:55])[n:36][c:37]2[O:38][CH2:39][C:40]([F:41])([F:42])[F:43])[CH2:30][CH2:31]1