HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 2-Fluoro-5-hydroxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 2-Fluoro-5-methoxybenzoic acid | HCID 2774543 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-Fluoro-5-hydroxybenzoic acid | HCID 2774480 | — |
Reaction Conditions
| Temperature | 140 °C |
|---|
Reaction Steps
To 2-fluoro-5-methoxybenzoic acid (5.00 g, 29.4 mmol) was added 49% aqueous HBr (50 mL) and glacial acetic acid (40 mL). The mixture was heated overnight at 140° C., cooled to RT, diluted with ice water and extracted with EtOAc. The organic layer was dried over Na2SO4, filtered and concentrated to yield 2-fluoro-5-hydroxybenzoic acid. MS m/z=157 [M+1]+. Calc'd for C7H5FO3: 156.11.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822514B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-0d749d0deff54f41803cec83004fd625 |
| Source note | uspto-grants-2014_09 |