HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 70087Generated: October 26, 2026
Water → (R)-2-{2-[4-(4-chloro-phenyl)-piperazin-1-yl]-6,7-dihydro-thieno[3,2-d]pyrimidin-4-ylamino}-3-methyl-butyramide
https://huagongshe.com/reaction/70087
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-(4-Chlorophenyl)piperazine | HCID 97478 | — |
| Reactant | (R)-2-(2-chloro-6,7-dihydro-thieno[3,2-d]pyrimidin-4-ylamino)-3-methyl-butyramide | HCID 59708380 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (R)-2-{2-[4-(4-chloro-phenyl)-piperazin-1-yl]-6,7-dihydro-thieno[3,2-d]pyrimidin-4-ylamino}-3-methyl-butyramide | HCID 59708455 | 88.2% |
Reaction Steps
400 mg (R)-2-(2-chloro-6,7-dihydro-thieno[3,2-d]pyrimidin-4-ylamino)-3-methyl-butyramide, 750 mg 1-(4-chloro-phenyl)-piperazine and 1.2 ml diisopropylethylamine are placed in 9 ml dioxane, then heated in the microwave for 1 hour and 45 minutes at 160° C. Then water is added. The precipitate formed is suction filtered and dried. 550 mg of the product are obtained as a powder. Analytical HPLC (method B): RT=3.03 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08822474B2 |
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| Source dataset | uspto-grants-2014_09 |
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| ORD ID | ord-f1f6c059d996401f91be22d95e1c3696 |
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| Source note | uspto-grants-2014_09 |
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