1-(4-Bromophenyl)-2,2,2-trifluoroethanol → 8-(2-Chloro-benzenesulfonyl)-2-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one

HRID 702500

Reaction equation

HRID 702500 reaction equation
[Br:22][c:23]1[cH:24][cH:25][c:26]([CH:29]([C:30]([F:31])([F:32])[F:33])[OH:34])[cH:27][cH:28]1.[Cl:1][c:2]1[c:3]([S:8](=[O:9])(=[O:10])[N:11]2[CH2:12][CH2:13][C:14]3([CH2:15][CH2:16][NH:17][C:18]3=[O:19])[CH2:20][CH2:21]2)[cH:4][cH:5][cH:6][cH:7]1>>[Cl:1][c:2]1[c:3]([S:8](=[O:9])(=[O:10])[N:11]2[CH2:12][CH2:13][C:14]3([CH2:15][CH2:16][N:17]([c:23]4[cH:24][cH:25][c:26]([CH:29]([C:30]([F:31])([F:32])[F:33])[OH:34])[cH:27][cH:28]4)[C:18]3=[O:19])[CH2:20][CH2:21]2)[cH:4][cH:5][cH:6][cH:7]1

Participants

3

Reactant 2

HCID 112190241-(4-Bromophenyl)-2,2,2-trifluoroethanolHCID 595779948-(2-Chloro-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one

Product 1

HCID 595780128-(2-Chloro-benzenesulfonyl)-2-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one

Sources & evidence

ORD record
ord-8d94152eeb1f4fa4a2c41ffff0604ef9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Linked notes

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