HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 3-(2,2,3,3,3-Pentafluoropropoxy)methyl-4-methyl-1-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 2,2,3,3,3-Pentafluoropropanol | HCID 9872 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 2-(Chloromethyl)-1-methyl-4-nitrobenzene | HCID 187952 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-(2,2,3,3,3-Pentafluoropropoxy)methyl-4-methyl-1-nitrobenzene | HCID 15070168 | — |
Reaction Steps
In 16.5 ml of dimethylformamide, 5.00 g (0.027 mol) of 2-methyl-5-nitrobenzyl chloride and 21.3 g (0.135 mol) of 2,2,3,3,3-pentafluoropropanol were dissolved. The solution was then added with 2.29 g (0.041 mol) of KOH pellets and stirred overnight. Dichloromethane was added and the precipitated salts were filtered out. The filtrate was acidified with dilute hydrochloric acid and then the solvents were distilled off.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04983209 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-fe6198eb9b0a45a8ba52b72219df5ea0 |
| Source note | uspto-grants-1991_01 |