HCID 15158253, compound → HCID 15158254, compound
Reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][N:9]2[C:21]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[C:15]3[C:10]2=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:3]=1>C(O)C.[Pd]>[N:7]1[CH:2]=[CH:3][C:4]([NH:8][N:9]2[C:21]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[C:15]3[C:10]2=[CH:11][CH:12]=[CH:13][CH:14]=3)=[N:5][CH:6]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
To a slurry of 10% Pd/C (1.0 g) and 0.8 g MgO in 5 ml of ethanol was added 4.0 g of N-(6-chloropyrimidin-4-yl)-9H-carbazol-9-amine in 12.0 ml of ethanol and the mixture was hydrogenated at atmospheric pressure at room temperature. When the reaction was complete, the mixture was filtered and the filtrate was evaporated to yield 6.2 g of an oil, which was preabsorbed on silica gel and eluted with 5% ethyl acetate/DCM on a silica gel column via the flash method. The desired fractions were evaporated to yield 2.4 g (61.5%) of a solid, N-(pyrimidin-4-yl)-9H-carbazol-9-amine, m.p. 177°-180° C.