1-Benzofuran-2-sulfonyl chloride → N-(5-chloro-2-{[(1-propyl-1H-imidazol-4-yl)methyl]thio}phenyl)-1-benzofuran-2-sulfonamide

HRID 70360

Reaction equation

HRID 70360 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:9][CH2:10][C:11]2[N:12]=[CH:13][N:14]([CH2:16][CH2:17][CH3:18])[CH:15]=2)=[C:6]([CH:8]=1)[NH2:7].[O:19]1[C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=2[CH:21]=[C:20]1[S:28](Cl)(=[O:30])=[O:29]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:9][CH2:10][C:11]2[N:12]=[CH:13][N:14]([CH2:16][CH2:17][CH3:18])[CH:15]=2)=[C:6]([NH:7][S:28]([C:20]2[O:19][C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[CH:21]=2)(=[O:29])=[O:30])[CH:8]=1

Participants

4

Reactant 2

HCID 27951721-Benzofuran-2-sulfonyl chlorideHCID 679722445-chloro-2-(((1-propyl-1H-imidazol-4-yl)methyl)thio)aniline

Product 1

HCID 67972567N-(5-chloro-2-{[(1-propyl-1H-imidazol-4-yl)methyl]thio}phenyl)-1-benzofuran-2-sulfonamideYield 48.1%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Following General Procedure B, the title compound (463 mg, 48%) was prepared from 5-chloro-2-(((1-propyl-1H-imidazol-4-yl)methyl)thio)aniline (587 mg, 2.082 mmol) and benzofuran-2-sulfonyl chloride (451 mg, 2.082 mmol) in pyridine (10 ml).

Sources & evidence

ORD record
ord-262cf25e335b4918804c373a81b2799e
Source dataset
uspto-grants-2014_09
Patent number
US08822530B2

Linked notes

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