Methyl Isocyanate → HCID 54355381, compound
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]([CH2:11][C:12]([O:14][CH3:15])=[O:13])[NH2:10])[CH:6]=[CH:7][CH:8]=1.[CH3:16][N:17]=[C:18]=[O:19]>C(#N)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]([CH2:11][C:12]([O:14][CH3:15])=[O:13])[NH:10][C:18]([NH:17][CH3:16])=[O:19])[CH:6]=[CH:7][CH:8]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of methyl [1-(3-methoxyphenyl)hydrazino]acetate (1.6 g) and methyl isocyanate (0.9 ml) in acetonitrile (20 ml) was heated under reflux for 1 h. The solvent was removed in vacuo and the residue was treated with ether to give the title compound (1.8 g) as a solid, m.p. 145°-146°.
Workup
- temperatureunder reflux for 1 h
- customThe solvent was removed in vacuo
- additionthe residue was treated with ether
Sources & evidence
- ORD record
- ord-ed98e318cb954589b186d1d1e54d3a87
- Source dataset
- uspto-grants-1991_01
- Patent number
- US04985427
Reaction notes
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