2-Aminomethyl-1-ethylpyrrolidine → N-[(1-Ethyl-2-pyrrolidinyl)methyl]-4-methylpyridazino[4,5-b]-indolizin-1-amine

HRID 704077

Reaction equation

HRID 704077 reaction equation
Cl[C:2]1[C:7]2[CH:8]=[C:9]3[N:14]([C:6]=2[C:5]([CH3:15])=[N:4][N:3]=1)[CH:13]=[CH:12][CH:11]=[CH:10]3.[NH2:16][CH2:17][CH:18]1[CH2:22][CH2:21][CH2:20][N:19]1[CH2:23][CH3:24]>>[CH2:23]([N:19]1[CH2:20][CH2:21][CH2:22][CH:18]1[CH2:17][NH:16][C:2]1[N:3]=[N:4][C:5]([CH3:15])=[C:6]2[N:14]3[C:9]([CH:10]=[CH:11][CH:12]=[CH:13]3)=[CH:8][C:7]=12)[CH3:24]

Participants

3

Reactant 2

HCID 1172952-Aminomethyl-1-ethylpyrrolidineHCID 157133121-Chloro-4-methylpyridazino[4,5-b]indolizine

Product 1

HCID 15713317N-[(1-Ethyl-2-pyrrolidinyl)methyl]-4-methylpyridazino[4,5-b]-indolizin-1-amine

Procedure

Following the procedure of Example 1, reaction of one equivalent of 1-chloro-4-methylpyridazino[4,5-b]indolizine and 27 equivalents of 2-(aminomethyl)-1-ethylpyrrolidine gave the title compound as the free base which was converted to the dihydrochloride salt, mp. 128° C. (dec.).

Sources & evidence

ORD record
ord-cb8667e7c7d846d7aecad49f86831872
Source dataset
uspto-grants-1991_01
Patent number
US04985560

Linked notes

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