HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Piperazinecarboxaldehyde → 4-(4-Methylpyridazino[4,5-b]indolizin-1-yl)-piperazinecarboxaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Piperazinecarboxaldehyde | HCID 82191 | — |
| Reactant | 1-Chloro-4-methylpyridazino[4,5-b]indolizine | HCID 15713312 | — |
| Product | 4-(4-Methylpyridazino[4,5-b]indolizin-1-yl)-piperazinecarboxaldehyde | HCID 15713337 | — |
Reaction Steps
Following the procedure of Example 1, reaction of one equivalent of 1-chloro-4-methylpyridazino[4,5-b]indolizine and 10 equivalents of piperazinecarboxaldehyde at 150° C. gave the title compound as the free base, which was purified by flash chromatography (silica gel, 1 to 20% methanol:ethyl acetate) and converted to the dihydrochloride salt (MeOH/etheral HCl/diethyl ether), mp 325° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04985560 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-8d64ab1e5902489abae5d19b42e1f524 |
| Source note | uspto-grants-1991_01 |