HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclobutylmethylamine → N-cyclobutylmethyl-10-[(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclobutylmethylamine | HCID 409746 | — |
| Reactant | 10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarbonyl chloride hydrochloride | HCID 20074886 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-cyclobutylmethyl-10-[(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide | HCID 15096214 | 48.6% |
Reaction Steps
By working in a manner similar to that described below in Example 103, but starting with 10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarbonyl chloride hydrochloride (3.4 g) in dichloromethane (100 cc) and with cyclobutylmethylamine (4.5 g), N-(cyclobutylmethyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide (1.7 g) is obtained, after recrystallization in isopropyl ether, in the form of white crystals, m.p. 133° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04985419 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-06a5e37eb5e34ec6b94a8ab08fc66f06 |
| Source note | uspto-grants-1991_01 |