1-(3-Methyl-3-phenylbutyl)-4-[2-(3-pyridyl)thiazolidin-4-ylcarbonyl]piperazine → YM 264

HRID 704446

Reaction equation

HRID 704446 reaction equation
[CH3:1][C:2]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)([CH3:24])[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]([CH:13]2[CH2:17][S:16][CH:15]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)[NH:14]2)=[O:12])[CH2:7][CH2:6]1.[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([OH:36])=[O:35]>C(O)C>[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([OH:36])=[O:35].[CH3:24][C:2]([C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)([CH3:1])[CH2:3][CH2:4][N:5]1[CH2:6][CH2:7][N:8]([C:11]([CH:13]2[CH2:17][S:16][CH:15]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)[NH:14]2)=[O:12])[CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 1314361-(3-Methyl-3-phenylbutyl)-4-[2-(3-pyridyl)thiazolidin-4-ylcarbonyl]piperazineHCID 444972Fumaric Acid

Product 1

HCID 6439322YM 264Yield 72.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 1-(3-methyl-3-phenylbutyl)-4[2-(3-pyridyl)thiazolidin-4-ylcarbonyl]piperazine (1.22 g) in ethanol (6 ml) was added fumaric acid (0.32 g) and the mixture was dissolved. The solution was stirred at room temperature for 2 hours and allowed to stand at room temperature for a day. The resultant crystals were collected by filtration, washed with ethanol and then dried to give 1.08 g of 1-(3-methyl-3-phenylbutyl]-4-[2-(3-pyridyl)thiazolidin-4-ylcarbonyl]piperazine fumarate.

Workup

  1. dissolutionthe mixture was dissolved
  2. waitto stand at room temperature for a day
  3. filtrationThe resultant crystals were collected by filtration
  4. washwashed with ethanol
  5. customdried

Sources & evidence

ORD record
ord-88b7f8b58e1348cf9f62240b69c336cd
Source dataset
uspto-grants-1991_01
Patent number
US04987132

Linked notes

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