HCID 15735587, compound → HCID 15735658, compound

Reaction equation

[CH:1]1(/[CH:7]=[C:8](\[CH2:12][P:13]([OH:19])([CH2:15][CH:16]([CH3:18])[CH3:17])=[O:14])/[C:9]([OH:11])=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[CH3:21]O>>[CH:1]1(/[CH:7]=[C:8](\[CH2:12][P:13]([OH:19])([CH2:15][CH:16]([CH3:17])[CH3:18])=[O:14])/[C:9]([O:11][CH3:21])=[O:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

Reactant 2

HCID 15735587HCID 15735587, compound

HCID 21893726Hydrochloride methanol

Product 1

HCID 15735658HCID 15735658, compound

Procedure

(Z)-3-cyclohexyl-2-(hydroxyisobutylphosphinoyl)methylpropenoic acid was treated in a similar manner as in Example 52 except that HCl-methanol was used instead of HCl-ethanol used in Example 52. The captioned compound was obtained as a colorless oil.

Workup

customThe captioned compound was obtained as a colorless oil

Sources & evidence

ORD record: ord-31f73867374c4bbc9bb28dc7d735f9e1
Source dataset: uspto-grants-1991_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04988681

Reaction notes

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