Sulfuric Acid → 2-Anilino-4-methyl-6-(1-propynyl)pyrimidine sulfate

HRID 704615

Reaction equation

HRID 704615 reaction equation
[NH:1]([C:8]1[N:13]=[C:12]([CH3:14])[CH:11]=[C:10]([C:15]#[C:16][CH3:17])[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:18](=[O:22])(=[O:21])([OH:20])[OH:19]>C(O)C>[S:18]([OH:22])([OH:21])(=[O:20])=[O:19].[NH:1]([C:8]1[N:13]=[C:12]([CH3:14])[CH:11]=[C:10]([C:15]#[C:16][CH3:17])[N:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 86296Mepanipyrim

Product 1

HCID 156154982-Anilino-4-methyl-6-(1-propynyl)pyrimidine sulfateYield 75%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Anilino-4-methyl-6-(1-propynyl)pyrimidine (2.2 g) was dissolved in 100 ml of ethanol, and 2 ml of concentrated sulfuric acid was added thereto and stirred for 1 hour at room temperature. The crystals deposited were filtered, and dried to afford 2.4 g of 2-anilino-4-methyl-6-(1-propynyl)pyrimidine sulfate (yield 75%). Melting point: 192°-195° C.

Workup

  1. filtrationThe crystals deposited were filtered
  2. customdried

Sources & evidence

ORD record
ord-779349712d9b4d689c7b0472cb9cb28a
Source dataset
uspto-grants-1991_01
Patent number
US04988704

Linked notes

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