Ethylenediamine → N'-(2-chlorophenyl)ethane-1,2-diamine

Participants

Role	Name	HCID	Charge
Reactant	Ethylenediamine	HCID 3301	—
Reactant	1-Bromo-2-chlorobenzene	HCID 12754	—
Reagent	Sodium t-butoxide	HCID 23676156	—
Catalyst	Phosphine, tris(4-methylphenyl)-	HCID 13956	—
Catalyst	Palladium (II) acetate	HCID 4144353	—
Solvent	Toluene	HCID 1140	—
Product	N'-(2-chlorophenyl)ethane-1,2-diamine	HCID 12666392	0%

Reaction Conditions

Temperature	140 °C

Reaction Steps

Ref: R2239 To a mixture of 1-bromo-2-chlorobenzene (0.824 g, 4.30 mmol), tri-p- tolylphosphine (0.262 g, 0.86 mmol), sodium 2-methylpropan-2-olate (0.414 g, 4.30 mmol), diacetoxypalladium (0.097 g, 0.43 mmol) in toluene (4 mL) was added ethane-1,2-diamine (1.293 g, 21.52 mmol). The mixture was heated with microwave at 140 °C for 1 h. No product was formed.

Provenance & Evidence

Source dataset	750 AstraZeneca ELN dataset
ORD ID	ord-5911a740f60145b0bc355f2a886b772f
Source note	750 AstraZeneca ELN dataset