(3R)-3-fluoropyrrolidine hydrochloride → HCID 178441821, compound

HRID 705130

Reaction equation

HRID 705130 reaction equation
[CH2:1]([C:5]1[N:6]=[C:7]([NH:21][CH2:22][C:23]2[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH3:32])[CH:24]=2)[C:8]2[NH:13][N:12]=[C:11]([C:14]#[C:15][CH2:16][CH2:17][CH2:18][CH2:19]Cl)[C:9]=2[N:10]=1)[CH2:2][CH2:3][CH3:4].Cl.[F:34][C@@H:35]1[CH2:39][CH2:38][NH:37][CH2:36]1>>[CH2:1]([C:5]1[N:6]=[C:7]([NH:21][CH2:22][C:23]2[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH3:32])[CH:24]=2)[C:8]2[NH:13][N:12]=[C:11]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][N:37]3[CH2:38][CH2:39][C@@H:35]([F:34])[CH2:36]3)[C:9]=2[N:10]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 2759162(3R)-3-fluoropyrrolidine hydrochlorideHCID 178441818HCID 178441818, compound

Product 1

HCID 178441821HCID 178441821, compound

Procedure

Prepared similarly to Intermediate 24 from 5-butyl-3-(6-chlorohex-1-yn-1-yl)-N-(3,4-dimethoxybenzyl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine and (R)-3-fluoropyrrolidine hydrochloride

Sources & evidence

ORD record
ord-902425f75cf444ce822f9aef9a09ae9f
Source dataset
uspto-grants-2015_11
Patent number
US09173872B2

Linked notes

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