4-Fluoropiperidine hydrochloride → 5-Butyl-N-(2,4-dimethoxybenzyl)-3-(5-(4-fluoropiperidin-1-yl)pentyl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine

HRID 705133

Reaction equation

HRID 705133 reaction equation
[CH2:1]([C:5]1[N:6]=[C:7]([NH:25][CH2:26][C:27]2[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][C:28]=2[O:35][CH3:36])[C:8]2[NH:13][N:12]=[C:11]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][N:19]3[CH2:23][CH2:22][C@H:21]([F:24])[CH2:20]3)[C:9]=2[N:10]=1)[CH2:2][CH2:3][CH3:4].[CH2:37](C1N=C(NCC2C=CC(OC)=CC=2OC)C2NN=C(C#CCCCCl)C=2N=1)CCC.Cl.FC1CCNCC1>>[CH2:1]([C:5]1[N:6]=[C:7]([NH:25][CH2:26][C:27]2[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][C:28]=2[O:35][CH3:36])[C:8]2[NH:13][N:12]=[C:11]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][N:19]3[CH2:23][CH2:22][CH:21]([F:24])[CH2:37][CH2:20]3)[C:9]=2[N:10]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 3

HCID 27591584-Fluoropiperidine hydrochlorideHCID 1784418105-Butyl-3-(5-chloropent-1-yn-1-yl)-N-(2,4-dimethoxybenzyl)-1H-Pyrazolo[4,3-d]pyrimidin-7-amineHCID 178441816(5)-5-Butyl-N-(2,4-dimethoxybenzyl)-3-(5-(3-fluoropyrrolidin-1-yl)pentyl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine

Product 1

HCID 1784418145-Butyl-N-(2,4-dimethoxybenzyl)-3-(5-(4-fluoropiperidin-1-yl)pentyl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine

Procedure

Prepared similarly to Intermediate 25 from and 5-butyl-3-(5-chloropent-1-yn-1-yl)-N (2,4-dimethoxybenzyl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine and 4-fluoropiperidine hydrochloride

Sources & evidence

ORD record
ord-4fa57fafee0f4f20b7aec840fdeaceb0
Source dataset
uspto-grants-2015_11
Patent number
US09173872B2

Linked notes

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