Ethanol → HCID 49856399, compound
Reaction equation
[N:1]1([C:6]2[CH:7]=[C:8]3[C:13](=[CH:14][CH:15]=2)[N:12]=[C:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]=[CH:9]3)[CH:5]=[CH:4][N:3]=[CH:2]1.C([OH:24])C>>[OH2:24].[N:1]1([C:6]2[CH:7]=[C:8]3[C:13](=[CH:14][CH:15]=2)[N:12]=[C:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]=[CH:9]3)[CH:5]=[CH:4][N:3]=[CH:2]1Participants
3
Procedure
3 g of 6-(1H-imidazol-1-yl)-2-phenylquinazoline are suspended in 80 mL of ethanol, the suspension is heated at reflux for 10 minutes, and then filtered while hot, the resulting solution is added at room temperature to 80 mL of water, with stirring, stirring is continued for a further 5 min and the mixture is then filtered and dried at 20° C., 10 mmHg, for 12 hours. 2.3 g (75%) of product are obtained in the form of a yellow powder. The crystals obtained are analysed. XRPD: Form C. Form C is similarly obtained by precipitating the product from methanol/H2O.
Workup
- temperaturethe suspension is heated
- temperatureat reflux for 10 minutes
- filtration