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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 7077Generated: October 26, 2026

4-hydroxy-N-(3-iodophenyl)-3-methoxyphenylacetamide → 4-hydroxy-3-methoxy-N-[2-(2-phenylethynyl)phenyl]-phenylacetamide

https://huagongshe.com/reaction/7077

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-hydroxy-N-(3-iodophenyl)-3-methoxyphenylacetamideHCID 12096660—
Reactant4-hydroxy-N-(2-iodophenyl)-3-methoxyphenylacetamideHCID 22019613—
Product4-hydroxy-3-methoxy-N-[2-(2-phenylethynyl)phenyl]-phenylacetamideHCID 22019673—

Reaction Steps

Instead of Intermediate 1 in Example 36, 4-hydroxy-N-(2-iodophenyl)-3-methoxyphenylacetamide is treated in a similar manner to Example 36 to give the desired compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07084176B2
Source datasetuspto-grants-2006_08
ORD IDord-89b0d7fa5702421e85b242cc98976b63
Source noteuspto-grants-2006_08