(1-Bromoethyl)benzene → 2,3-Dimethoxy-5-[(1-phenylethyl)sulfanyl]pyridine

Reaction equation

Cl[C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[CH2:5][S:6][C:7]1[CH:8]=[C:9]([O:15][CH3:16])[C:10]([O:13][CH3:14])=[N:11][CH:12]=1.Br[CH:21](C1C=CC=CC=1)C>>[CH3:14][O:13][C:10]1[C:9]([O:15][CH3:16])=[CH:8][C:7]([S:6][CH:5]([C:4]2[CH:17]=[CH:18][CH:19]=[CH:2][CH:3]=2)[CH3:21])=[CH:12][N:11]=1

Participants

Reactant 2

HCID 11454(1-Bromoethyl)benzene

HCID 711858335-(3-Chlorobenzylthio)-2,3-dimethoxypyridine2×

Product 1

HCID 711861842,3-Dimethoxy-5-[(1-phenylethyl)sulfanyl]pyridine

Procedure

Prepared as described for 5-(3-chlorobenzylthio)-2,3-dimethoxypyridine (Intermediate 8) but using (1-bromoethyl)benzene instead of 1-(bromomethyl)-3-chlorobenzene.

Workup

customPrepared

Sources & evidence

ORD record: ord-378da76c1fa8438ca762c79123666b16
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09180122B2

Reaction notes

Loading…