Methanesulfonyl chloride → HCID 56848687, compound

Reaction equation

Cl.[NH2:2][CH:3]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[C:31]([F:34])([F:33])[F:32])[CH2:4][NH:5][C:6](=[O:24])[CH2:7][N:8]1[C:12](=[O:13])[N:11]([CH2:14][CH2:15][O:16][CH3:17])[C:10]([C:18]2[S:19][C:20]([Cl:23])=[CH:21][CH:22]=2)=[N:9]1.[CH3:35][S:36](Cl)(=[O:38])=[O:37]>>[Cl:23][C:20]1[S:19][C:18]([C:10]2[N:11]([CH2:14][CH2:15][O:16][CH3:17])[C:12](=[O:13])[N:8]([CH2:7][C:6]([NH:5][CH2:4][CH:3]([NH:2][S:36]([CH3:35])(=[O:38])=[O:37])[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[C:31]([F:32])([F:33])[F:34])=[O:24])[N:9]=2)=[CH:22][CH:21]=1

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 89764091HCID 89764091, compound

Product 1

HCID 56848687HCID 56848687, compound

Procedure

Analogously to the procedure of Example 68, 29 mg (46 μmol) of the compound of Example 60A were reacted with methanesulphonyl chloride. This gave 25 mg (92% of theory) of the title compound.

Sources & evidence

ORD record: ord-d49192dd9046487bb72479e4bba8301b
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09180120B2

Reaction notes

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