HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Octyne → 5-((2'-(Trifluoromethyl)biphenyl-4-yl)ethynyl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Octyne | HCID 12370 | — |
| Reactant | 5-Iodo-1H-indole | HCID 2782313 | — |
| Reactant | 5-Iodo-2-tritylisoindoline | HCID 66726248 | — |
| Reactant | 4'-Ethynyl-2-(trifluoromethyl)biphenyl | HCID 86661806 | — |
| Product | 5-((2'-(Trifluoromethyl)biphenyl-4-yl)ethynyl)-1H-indole | HCID 66726787 | 86% |
Reaction Steps
When the product of Step A was substituted for 1-octyne and 5-iodoindole was substituted for 5-iodo-2-tritylisoindoline in Example 2, Step D, the similar process afforded the title compound in 86% yield, as a colourless paste. 1H-NMR (CDCl3) 7.56 (broad s, 1H); 7.28-7.4 (m, 5H); 7.46 (tr, 1H, J=7.25 Hz); 7.53-7.58 (m, 3H); 7.73 (d, 1H, J=7.85 Hz); 7.87 (s, 1H); 8.23 (broad s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181182B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-ff943ebbc5264be787413209da71d288 |
| Source note | uspto-grants-2015_11 |