5-(Oct-1-ynyl)-1H-indole → 2,2,2-Trifluoro-1-(4-octylindolin-1-yl)ethanone

Participants

Role	Name	HCID	Charge
Reactant	5-(Oct-1-ynyl)-1H-indole	HCID 66726751	—
Reactant	2,2,2-Trifluoro-1-(4-(oct-1-ynyl)indolin-1-yl)ethanone	HCID 86661816	—
Product	2,2,2-Trifluoro-1-(4-octylindolin-1-yl)ethanone	HCID 86661815	77%

Reaction Steps

When the product of Step B was substituted for 5-(oct-1-ynyl)-1H-indole in Example 3, Step B, the identical process afforded the title compound in 77% yield, as colourless oil. 1H-NMR (CDCl3) 0.86 (m, 3H); 1.28 (m, 10H); 1.57 (m, 2H); 2.54 (tr, 2H, J=8 Hz); 3.17 (tr, 2H, J=8.3 Hz); 4.27 (tr, 2H, J=8 Hz); 6.97 (d, 1H, J=7.6 Hz); 7.2 (tr, 1H, J=7.9 Hz); 8.04 (d, 1H, J=8.1 Hz).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09181182B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-0f794ef260a44a3084f45e4bfafe5218
Source note	uspto-grants-2015_11