5-(Oct-1-ynyl)-1H-indole → 2,2,2-Trifluoro-1-(7-octyl-1,2,4,5-tetrahydrobenzo[d]azepin-3-yl)ethanone

Participants

Reaction Steps

When the product of Step C was substituted for 5-(oct-1-ynyl)-1H-indole in Example 3, Step B, the similar process afforded the title compound in 90%, as pale oil. 1H-NMR (CDCl3) 0.87 (tr, 3H, J=6.96 Hz), 1.25-1.28 (m, 10H); 1.4-1.46 (m, 2H); 2.50-2.56 (m, 2H); 2.90-2.95 (m, 4H); 3.64-3.66 (m, 2H); 3.73-3.75 (m, 2H); 6.81-7.07 (m, 3H).

Provenance & Evidence