Acetic Acid → 8-Bromo-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline

HRID 711383Notes

Reaction equation

HRID 711383 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8]([NH:12][NH2:13])=[N:9]2)=[CH:4][CH:3]=1.[CH3:14][C:15](O)=O>O>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8]3[N:9]2[C:14]([CH3:15])=[N:13][N:12]=3)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 52002657-Bromo-2-hydrazinylquinoxaline

Product 1

HCID 668035548-Bromo-1-methyl-[1,2,4]triazolo[4,3-a]quinoxalineYield 91%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 7-bromo-2-hydrazinylquinoxaline (200 mg, 0.84 mmol) and AcOH (5 mL) was refluxed overnight. After cooling to r.t., the mixture was treated with water (10 mL); the solid was collected on a filter and dried by vacuum to give 8-bromo-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline as gray solid (200 mg, yield: 91.0%).

Workup

  1. temperaturewas refluxed overnight
  2. customthe solid was collected on
  3. filtrationa filter
  4. customdried by vacuum

Sources & evidence

ORD record
ord-992eb34c765e4fa783bacf5e677d8d00
Source dataset
uspto-grants-2015_11
Patent number
US09181264B2

Reaction notes

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